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Harman SM, Metter EJ, Tobin JD, et al

The schedule mirrors the clinical-trial protocols that drove substantial weight loss around 20% of body weight over 72 weeks on the 15 mg dose [2] while holding gastrointestinal effects down through gradual escalation [1] [4]

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Animal toxicology studies have not shown organ toxicity at therapeutic doses over weeks, but extrapolating rodent data to human multi-month cycles is not scientifically supported