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Furthermore, IGFBP3 has been shown to exhibit antiproliferative and proapoptotic actions via an IGF-1/IGF-1R-independent mechanism [103]
J Clin Oncol 28(3):398-404, 2010

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However, the global impact of changing treatment regimen recommendations within a short period of time and the need to wait until more information is available from surveillance studies highlight the necessity for alternative sources of safety data

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