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PI3K/Akt is a pathway that modulates pro- and anti-inflammatory processes, with the capacity to promote the production of pro-inflammatory cytokines (IL-6, IL-1) (164169) while concomitantly reducing excessive inflammation by inducing anti-inflammatory cytokines such as IL-10 (170172) Inhibition of FOXO by Akt leads to the inhibition of autophagy, production of antioxidant enzyme and apoptosis, thereby promoting a state of chronic inflammation (173, 174)

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There it serves to regulate gut motility, secretion and communication between the gut and the brain (the so-called gut-brain axis )

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The antioxidant enzyme activity of nanomaterials is influenced by factors including size, morphology, surface modification, and composition (185)