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Sugawara J, Mitsui-Saito M, Hayashi C, Hoshiai T, Senoo M, Chisaka H

Therefore, focus has been drawn towards targeting the glutathione antioxidant system in tumor cells as a therapeutic approach using drugs to target glutathione directly, indirectly, or by using glutathione-based prodrugs (Figure 4) [15]

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PLoS One (2011) 6(7):e21924

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Methods: A PRISMA-guided systematic review was conducted using PubMed and MEDLINE databases with search terms glutathione AND topical AND skin OR dermatology. From 446 articles, only clinical trials on topical glutathione were included, excluding reviews, animal studies, and research on oral or intravenous glutathione