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ASVs, amplicon sequence variants

With respect to VPA, this agent depletes carnitine stores, especially during long-term or high-dose therapy, through various synergistic mechanisms [22,38-41]

Acetyl L-Carnitine may help support brain health and cognitive function by increase levels of acetylcholine, an important neurotransmitter.* It crosses the blood-brain barrier and improves absentmindedness and mild memory problems associated with aging.* Acetyl L Carnitine supports older adults by lessening fatigue in body and mind.* It may also help promote peripheral nerve health and vibratory sensation.* Along with L-Carnitine, Acetyl-L-Carnitine may help promote sperm motility and male fertility.*

doi: 10.1001/jama.280.7.605

This exciting area has become a hot topic in basic research and will bring so many opportunities in translational medicine, however, there are still many challenges to be solved

Sandor, A., Pecsuvac, K., Kerner, J., and Alkonyi, I