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These symptoms are typically temporary and resolve as your body adjusts to the medication, usually within a few weeks

Autophagy in kidney homeostasis and disease

doi: 10.1172/JCI27523

10.1038/s41398-021-01573-7 [DOI] [PMC free article] [PubMed] [Google Scholar] Du C., Volkow N

The antimalarial medication quinine has long been used for cramp relief, but after increasing reports of side effects, most severely disseminated intravascular coagulopathy [193], the FDA limited and provided guidelines for the amount of quinine readily available in common formulations [194]

Thus, high doses of caffeine are regarded to increase renal clearance and promote more rapid excretion of many drugs and their metabolites from the body
