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Glucose and G6P are proposed to be direct activators of LXR, which in turn would lead to the activation of SREBP-1c to promote the expression of lipid and cholesterol synthesis genes (226)

Diabetes 68(5):1054-61 2019 PMC6477902 Boroda S, Takkellapati S, Lawrence RT, Entwisle SW, Pearson JM, Granade ME, Mullins GR, Eaton JM, Villen J, Harris TE