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Chronic hyperglycemia results in the suppressed activity of mTOR associated with AMP-activated protein kinase-induced increase in ROS formation and enhanced expression of thioredoxin interacting protein (TXNIP) a potential sensor of glucose and oxidative stress (Akpoveso et al

In this way, the replacement of iron and copper by zinc could prevent the formation of highly reactive radicals because zinc is catalytically inert [11,28]

[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Rasheed Z

doi: 10.1186/s12967-024-05026-9 183 YuF.WangX.RenH.ChangJ.GuoJ.HeZ.et al

2023;19: e2300104

Suppression of reticulocalbin 1 gene expression reduces bone marrow mononuclear cell activity in patients with AML, further confirming the crucial role of cellular pyroptosis in AML pathogenesis (113)