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Through its many physiological functions (Figure 4) glutathione has a major role in tumors with a number of publications showing that increased cellular levels of glutathione are necessary for tumor initiation and proliferation [48,49]

GSH-triggered prodrugs Because intracellular GSH levels are typically elevated in tumor cells relative to normal tissues, this redox imbalance has been exploited as a tumor-associated trigger for prodrug activation and selective cytotoxicity 214

Since the liver is the major source of IGF and IGFBP production, they examined whether levels of IGFs (IGF-1 and IGF-11) and IGFBPs (IGFBP-1 and IGFBP-3) differed when insulin was infused into the portal or peripheral vascular system [13]