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Although the overall evidence suggests that at least a subset of patients with ME/CFS exhibit reduced cortisol output, some cohorts show only modest reductions, preserved cortisol output, or context-dependent abnormalities rather than stable hypocortisolism, indicating that HPA-axis dysfunction in ME/CFS is likely heterogeneous and multifactorial rather than a specific or uniform neuroendocrine abnormality (Tomas et al., 2013

doi: 10.3390/cancers13164081 157 PratMSalonMAllainTDubreuilONolGPreisserLet al

Donor leukocyte infusions in 140 patients with relapsed Malignancy after allogeneic bone marrow transplantation

Conversely, under pathological conditions, the host immune systems ability to regulate bacterial translocation becomes compromised

Thus, the evidence of preserved synaptic function [86] and long term improvement in learning in rats treated with L-carnitine after injury [86] is particularly important, and more studies determining functional outcomes are needed

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