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An increase in expression of cellular protectant genes occurs at lower doses of H 2 O 2 than required for HR, and takes place in healthy cells adjacent to necrotic, HR-type lesions in infected leaves (Levine et al., 1994

This targeted promotion of MMP-9, combined with inhibition of MMP-1 and MMP-2, represents a nuanced remodeling signal: clear the path for migrating cells while preserving the structural collagen matrix being laid down

Systematic efforts that integrate in vivo functional genetics, spatial metabolomics/lipidomics and microenvironment-informed tumor models will be essential to map where CoQ 10 -based defenses become rate limiting for tumor fitness

Interestingly, two main responses have been observed with MitoQ supplementation in mice, depending on the pregnancy period of administration

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10.1038/sigtrans.2017.23 63 LiuS.JinX.GeY.DongJ.LiuX.PeiX.et al (2025)