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Magnetic resonance imaging (MRI) in MELAS patients typically reveals cortical lesions, primarily in the occipital and parietal lobes, presenting as low signal intensity on T1-weighted imaging (WI) and high signal intensity on T2WI

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PAMAM dendrimers can disrupt existing fibrils and interfere with the development of A1-28 in AD brain, which can delay the progression of AD (Klajnert et al., 2006)

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