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As mentioned above, LAT1 can affect the bioavailability of cysteine since it is the main methionine transporter, being its expression related to chemoresistance (128)

N Engl J Med 322(26):18601866

It is plausible, therefore, that chondroitin sulphate and glucosamine sulphate supplementation may be most effective in patient populations with low dietary sulphur, such as vegetarians or those who consume little red meat

Specifically, one large meta-analysis found that levels of KYN, KA, tryptophan (TRP), and the KA to quinolinic acid (QA) ratio were decreased in individuals with BD (Marx et al., 2021)

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