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Cachexia is a metabolic syndrome associated with muscle and weight loss connected to health issues like cancer, chronic obstructive pulmonary disease (COPD) , and heart failure
(2023b)

43 This suggests that this mtDNA mutation is a risk factor that requires interactions with nuclear mutations, polymorphisms or epigenetics and/or environmental triggers or modulators in order for the disease phenotype to be expressed

This complication is sometimes referred to as radiation proctitis (Bansal 2016
Eur J Intern Med (2006) 17:54550
Lack of definition is often a product of facial volume loss and skin laxity