glutathione reductase deficiency anemia Disorder of Metabolism The importance of glutathione in

Activated Nrf2 binds to antioxidant response elements (AREs) and translates to the nucleus, ultimately initiating the expression of downstream target genes, such as heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutamatecysteine ligase catalytic (GCLC) subunit

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doi: 10.1016/j.redox.2017.08.007 148

In addition, exosomal circRNA 101093 regulates overall arachidonic acid (AA) levels and induces N-arachidonyl taurine (NAT) production through interaction with fatty acid binding protein 3 (FABP3), resulting in desensitization of LUAD cells to ferroptosis [164]

To address the reactivities of the redox-sensitive cysteinyl residues, we also analyzed the recombinant monothiol roGFP2 variants roGFP2 C151S and roGFP2 C208S and detected small but reproducible glutathionylation-dependent changes of fluorescence at both excitation wavelengths for roGFP2 C151S (SSG) and roGFP2 C208S (SSG) (Fig

doi: 10.1016/j.phymed.2024.155347 25 HeidarzadehpilehroodR.PirhoushiaranM.AbdollahzadehR.Binti OsmanM.SakinahM.NordinN.et al