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These results as mentioned above indicate that targeting VEGF may represent an effective key factor to deter the subsequent and deleterious effect of activation of its downstream molecular pathways

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doi: 10.1021/acs.chemrestox.5b00171 6 JimnezIUDaz-DazECastroJSRamosJPLenMCAlvarado RosJAet al

PI3K/Akt and MAPK pathways have been shown to mediate downstream signaling of IGF-1 in these cells, although the relative importance of these pathways seems to differ depending on the model systems analyzed

One supplement that has gained attention in recent years is glutathione, known for its antioxidant properties and role in detoxification

Conversely, the human body has natural antioxidant systems, which include an enzymatic antioxidant system comprising superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), among others (Napolitano et al., 2021)