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Example 1 uses proportional tapering

This design constraint reduced the impact of polar and charged groups, enabling a focused examination of how molecular size affects permeability

doi: 10.1261/rna.7240905 20 BasuS.BinderR

In addition, pH-responsive nanomaterials can release drugs in the acidic environment of the stomach, increasing the concentration of drugs at the site of infection, thereby enhancing the antibacterial effect and reducing the impact on the gut microbiota

That means stimulating cellular processes like angiogenesis (new blood vessel formation), collagen synthesis, fibroblast proliferation, or stem cell activation