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Those tissue-specific [110] and transgenerational epigenetic actions of GCs are not limited to DNA m but were also found to include histone modifications (acetylation and deacetylation) [111], microRNAs (miRNAs) abundance [112] and chromatin remodelling [113]

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Among Korean patients, sunitinib combined with XELOX (oxaliplatin + capecitabine) in patients with advanced GC (121) had an mPFS of 5.5-8.0 months and an ORR of 43.5-45.5%

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