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Immortalized cell lines, while convenient and reproducible, often lack the functional complexity, genetic diversity, and physiological responses of primary kidney cells, limiting their ability to model individual variations in renal function and pathology

In cirrhosis, CB1 receptors are upregulated and expressed in fibrogenic liver cells, and CB1 inhibition has been linked to reduced fibrosis and lower TGF- signaling

Stelzer, G

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In the context of Long COVID, the SARS-CoV-2 virus binds directly to ACE2 receptors, which are highly expressed on these endothelial cells

Melatonin is generally effective and well-tolerated