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Exposure to heat can quickly degrade the vitamin, making it less effective

Frontiers in Pharmacology, 8 , 52

On the other hand, some studies show that taking a high dosage of vitamin B12, such as 1000 mcg, can be an alternative to vitamin B12 injections for those who are lacking the intrinsic factor protein in their diet, or for those with other conditions that do not allow them to absorb their vitamin B12 intake fully

others dont (see the page on tolerance)

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Cycle breaks become mandatory if you have been on protocol for 12+ weeks continuously or if response has dropped significantly despite dose adjustment