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It was originally developed as a potential anti-obesity drug due to its ability to influence fat metabolism without causing the same growth-promoting effects associated with full HGH therapy (review)

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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

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