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IDPs/IDRs rarely exhibit enzymatic catalysis, with a few exceptions where collapsed IDPs show catalytic activity (Uversky et al., 1996

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ORR is defined as the proportion of patients with a best response of complete response (CR) or partial response (PR) by the RECIST 1.1 criteria recorded between Day 1 of the study and the date of objectively documented progression per RECIST 1.1 or the date of subsequent anti-cancer therapy, whichever occurred first

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GSH can also conjugate L-dopaquinone in the presence of glutathione S-transferase and yield glutathionyldopa, a precursor of cysteinyldopa