glutathione degradation ferroptosis Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Peroxidase 4 to Trigger Ferroptosis as a therapeutic target

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690 Bioinformatics analysis and qPCR results of rat spinal cord tissue showed that mRNA levels of PTGS2, JUN, RELA, ATF3, TLR4, HMOX1, and STAT3 were upregulated, while mRNA levels of MAPK9, MAPK1, and VEGFA were downregulated

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This led to reduction in physical activity, with a negative impact on nutrition behavior and resultant composition of gut microbiota, with major implications in the severity of C19 (3)