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The population frequency of the rs1801222A allele is 20%, ranging from 15% in East Asians to 29% in Europeans [31], suggesting that the variant will impact all population groups treated with metformin

Gradient elution was performed starting at a mobile phase composition of 99% solvent A and 1% solvent B, where solvent A consisted of 5 mM ammonium acetate with 0.1% acetic acid adjusted to pH 3.5, and solvent B was acetonitrile

Published online September 2006:335-341

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PMID 26748744