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3 Blocking proteasomal degradation leads to the accumulation of intracellular proteins and subsequent cellular stress, 4 which in turn inhibits proliferation and induces apoptosis of myeloma cells

They suggest inflammation/oxidative stress induced basal ganglia damage may be causing fatigue in both groups

The methyl donor or methyl group donor is the molecule which releases the methyl group during the methylation reaction

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Pyruvate dehydrogenase catalyses the conversion of pyruvate to acetyl-CoA that enter in the TCA cycle (Figure 4a)