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Moreover, GS is inactivated by extracellular glutamine because the presence of glutamine induces GS acetylation by p300/CBP protein, facilitating its ubiquitination and proteasomal degradation [79-81]

Zhang J, Chen L, Wang J, Lei Y, Huang Y, Xu J, Hu N, Huang W, Cui W, Luo X

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It isknown that ovarian steroid production (oestradiol and progesterone) can alter the secretions of the pituitary and hypothalamus.Moreover, hypothalamusinduced GnRH controls LH, FSH secretion known to regulate gonadal functions.In mammalian species, ghrelin hormone treatment inhibits the release of GnRH, LH, and FSH at the hypothalamic and pituitary levels.Adverse effects have been described in several species of fish.In gonads, ghrelin hormone also exerts inhibitory effects by altering steroid composition and germ cell production or viability in the ovaries and testicles

Common research areas include cellular signaling pathways, receptor binding assays, and comparative pharmacology studies