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4a,c and Supplementary Table 1b,c), followed by a further significant decline at 8 months (Fig

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[234] observed that there was a strong relation between TNF- and Kyn, Kyn/tryptophan, 3-HK and QA in the manic subgroup whereas in the depressed subgroup the KYNA/3-HK decreased and there was a strong association between interferon-y and Kyn pathway activation

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