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when cells are exposed to this stimulus, the NRF2Keap1 complex is disrupted, allowing NRF2 to escape and resulting in Keap1-mediated degradation
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94,297 Additionally, hyperglycemia-induced activation of protein PKC affects the expression of VEGF, promotes vasoconstriction, and induces hypoxia

The subsequent stage is known as meiosis and involves specialized cell division of primary spermatocytes, resulting in the formation of haploid spermatids
