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Kathleen Grant, Ph.D., senior scientist at the Oregon National Primate Research Center (OHSU Center for Womens Health), suggests that reproductive hormones particularly progesterone play a role in both when women choose to drink and how they respond to alcohol
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If you drink alcohol regularly, your stomachs lining and bodys ability to absorb vitamin B12 can be impacted

See below for more on whether non-deficient folks should consider B12 shots to improve their energy

The NHS hypokalaemia overview explains why it matters, and clinical references such as StatPearls on B12 deficiency treatment specifically flag monitoring potassium during the early loading phase in people who were severely deficient

Cobalamin Hypersensitivity Some people might be allergic to cobalamin , the active form of vitamin B12
