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Notably, cuproptosis is regulated by mitochondrial respiration, as supported by research indicating that mitochondria-dependent cells exhibit a sensitivity to copper ionophores nearly 1,000 times higher than cells undergoing glycolysis [12]

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However, the four following considerations suggest that this is not because of an increased need for O 2 detoxification but is more likely part of a stress response signaling pathway: (1) It is unclear that all the conditions that up-regulate sod-3 described above also increase oxidative stress

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