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AAV2-GAD gene therapy for advanced Parkinsons disease: a double-blind, sham-surgery controlled, randomised trial

[DOI] [PubMed] [Google Scholar] 31.Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

In this section, we discuss the biological mechanisms of RMT, recent advancements in therapeutic applications, and future directions for optimizing BBB drug delivery

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(2023) employed response surface methodology (RSM) integrated with genetic algorithmartificial neural network (GAANN) modeling, identifying optimal conditions as follows: 52 C, 1:30 solidliquid ratio (w/v), 167 min duration, and 0.01 mol/L NaOH, yielding 29.53% BSP recovery
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