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[DOI] [PubMed] [Google Scholar] 31.Opicapone as an adjunct to levodopa in patients with Parkinson's disease and end-of-dose motor fluctuations: a randomised, double-blind, controlled trial

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(2023) employed response surface methodology (RSM) integrated with genetic algorithmartificial neural network (GAANN) modeling, identifying optimal conditions as follows: 52 C, 1:30 solidliquid ratio (w/v), 167 min duration, and 0.01 mol/L NaOH, yielding 29.53% BSP recovery

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