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In: VernadakisAPrivatALauderJMTimirasPSGiacobiniE editors

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3.2.1 Quercetin and apoptosis Apoptosis is a form of programmed cell death characterized by specific morphological and biochemical changes such as cell shrinkage, membrane blebbing, chromatin condensation, DNA fragmentation, and caspase activation (Shi, 2004)

Furthermore, Schneider et al

Acid sensitivity and ultrastructure of the retrotrapezoid nucleus in Phox2b-EGFP transgenic mice

Given that ferroptosis involves non-apoptotic pathways culminating in compromised cell membrane integrity, it is hypothesized that ferroptosis significantly contributes to PA-induced cytotoxicity and may account for this apparent difference between assays measuring distinct cellular endpoints