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It has been shown to enhance antioxidant enzyme activity, including GPX4, SOD, and CAT, reducing oxidative damage and mitigating ferroptosis in MCAO/R Rats (Zhu W

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During the reperfusion phase, microglia and recruited macrophages can phagocytose and remove cell debris and dying cells, but living cells in the ischemic penumbra under sublethal conditions can also be phagocytosed and die due to exposure to the eat me signal phosphatidylserine (PS) (Neher et al., 2013)

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