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NNMT regulates methylation of nicotinamide, influencing intracellular pools of NAD+, a central cofactor in metabolic pathways
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Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
According to Cant et al., Cell Metabolism , increased NAD stimulates PGC-1 activity, driving mitochondrial biogenesis and substrate flexibility
