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During OXPHOS there is also production of reactive oxygen species (ROS), which are involved in the regulation of cellular function

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For the L-GSH supplementation group, there was a significant decrease in the levels of oxidized GSH in PBMCs ( Figure 4J ) and RBCs ( Figure 4K ), but not in plasma ( Figure 4I )

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Carter, V

By eliminating O 2 radicals, SODs reduce the risk of OH development by employing metal catalysed HaberWeiss-type reaction since, in comparison to spontaneous dismutation, the rate of this reaction is about 10,000 times faster [181]