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The Role of Neuroinflammation in Dementias

Superoxide anion radical (O 2 ), Hydrogen peroxide (H 2 O 2 ), and Hydroxyl ions (OH )] are produced in which different numbers of electrons have been transferred from O2 Absorption of radiant energy (UV rays , x-rays)- ionizing radiation can hydrolyze water into Hydroxyl (OH ) and hydrogen (H) free radicals Rapid bursts of Superoxide production occurs in the activated polymorphonuclear leukocytes during inflammation Nitric oxide NO is produced by endothelial cells, macrophages, neurons and other cell types NO can act as free radical and can also be converted into highly reactive peroxynitrite anion (ONOO ), NO 2 and NO 3 Enzymatic metabolism of exogenous chemicals and drugs generate free radicals e.g

[63] demonstrated that pharmacologically enhancing mitophagy (e.g., with urolithin A) can reduce mtDNA leakage and ameliorate inflammation in APP/PS1 mice

Why was it removed and then put back