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After treatment, brain tissues were harvested and evaluated for oxidative stress biomarkers (8-OHdG, MDA, GPx, GSH, GST, SOD), pro-inflammatory cytokines (MPO, NF-B, TNF-), ion transport enzymes (Na/K ATPase, Ca ATPase), neurotransmitter levels (dopamine, serotonin, AChE), and the apoptotic marker caspase-3

Directions for use By intramuscular, subcutaneous or intravenous injection Dogs and Cats: 0.5 - 1mL Sheep, Horses and Cattle: 1 - 4mL Repeat after 1-2 weeks

However, systematic analysis of what other p53 mutants are responsive to APR-246 is currently lacking