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These modifications may cause an imbalance in the cells antioxidant defense system and these inflammatory factors homeostasis, which ultimately results in a pathophysiological malfunction and apoptosis [30]

Over 29 days of treatment, the peptide inhibited pulmonary artery muscularization (the thickening and stiffening of pulmonary arteries that drives this condition), prevented right heart hypertrophy (the enlargement of the right ventricle that occurs when it has to pump against increased resistance), and significantly decreased mortality

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ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

Zustzlich zeigen sie eine hohe Affinitt zu Histonproteinen, vor allem zu linker Histon-H1 sowie zu H3- und H4-Varianten [2, 9]

Cureus, [online] 17(1).