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However, when we analyzed neighboring units within the crystal structures of C0362 (both SeMet and wild-type), no obvious dimerization interface was observed

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In contrast, the erastin-induced oxidative stress and cell death could be prevented in HT-1080 and other cancer cell lines by Trolox (a vitamin E analog), the iron chelator deferoxamine (DFO), the MEK inhibitor U0126, and the glutathione peroxidase mimetic ebselen

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Cleavage of GCLC occurs at Asp 499 within the sequence AVVD 499 G, which is located upstream of Cys 553 thought to be important for disulfide bond formation with GCLM [35,45]

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Protecting the Endothelium The endothelium is the thin layer of cells that lines your blood vessels and heart

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