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demonstrated an in vivo increase in proteoglycan synthesis by NP cells following exogenous administration of growth factors TGF1

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striatal blood-brain barrier permeability in ParkinsonS disease

Adverse Events (AEs): PRODUODOPA: 85% of patients reported AEs, 22% discontinued due to AEs, 8% experienced severe AEs, and 70% had AEs related to the study drug

3941 Traditional intranasal devices of liquid formulations, such as droppers and spray pumps, face challenges in delivering drugs to the olfactory epithelium because of their location in the upper part of the nose and the restrictions imposed by the nasal turbinate