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Among the remaining subjects, we further excluded those who received a diagnosis of bipolar disorder during the follow-up assessment (n = 9), those with missing metabolite data due to the lack of blood samples (n = 158) and those who did not complete the Inventory for Depressive Symptoms questionnaire (n = 33)

Pharmacophore 11, 112

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Window 2, which corresponds to proteins and peptides, ranges from 1800 to 1500 cm 1

Therefore, the PFOS-mediated apoptosis started with ERK1/2 activation, which was followed by ER stress and autophagy induction

Once produced, TMA is absorbed into the bloodstream and transported to the liver, where it undergoes further oxidation to form TMAO via the enzyme FMO-3 [23, 25]