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doi: 10.1152/physiolgenomics.2001.5.1.21

Rare cases of allergic contact dermatitis have been described with prolonged copper exposure, so persistent or worsening inflammation should prompt discontinuation and medical evaluation

It is felt to be superior to cyanocobalamin and the methyl form is better and easier to absorb

The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency

If that's insufficient for your risk tolerance, wait for longer-duration data to publish

As the causative bacteria die off due to antibiotics, inflammatory agents are released and temporarily worsen symptoms before improvement is noted
