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B12 cannot be synthesized by the human body

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Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women

Another possibility is that declines in tHcy and MMA observed during pregnancy are phenomena not clearly related to deficiency status and that vitamin B-12 supplementation increased maternal blood vitamin B-12 concentration, as well as infant markers of vitamin B-12 status

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