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2,3,7 Classic features are manifested in 3% to 7% of the population and in up to 20% of women under the broadest definition

The evolution of FolEIB in bacteria may be reflective of a GCYH that evolved under the influence of dual stressors, oxidative/nitrosative stress and Zn II limitation, reminiscent of DskA2 vs DksA (Section 4.2.2)