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Interaction with inflammatory mediators Alterations in pro- and anti-inflammatory cytokines, including interleukin (IL)-6, IL-1 and tumour necrosis factor (TNF), have been reported in populations with depression, and to a lesser extent, bipolar disorder and schizophrenia.16,17 These inflammatory cytokines are potential contributors to the underlying pathophysiology of these disorders

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De Rosa SC, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 2000 Oct;30(10):841-2. [PMID: 11029607] 8. Atkuri KR, Mantovani JJ, Herzenberg LA, et al. N-Acetylcysteinea safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol. 2007 Aug;7(4):355-9. Review. [PMID: 17602868]

Intra-articular injection of RIPK3 or MLKL inhibitors has been demonstrated to significantly prevent cartilage degeneration and synovial inflammation, revealing potential therapeutic targets for temporomandibular joint osteoarthritis (He et al., 2022)

doi: 10.3390/foods6100092.CrossRefGoogle ScholarPubMed Ibrahim Fouad, G (2020) Synergistic anti-atherosclerotic role of combined treatment of omega-3 and co-enzyme Q10 in hypercholesterolemia-induced obese rats

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