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The central, hydrophobic, non-amyloid component (NAC) region of S has been described as highly aggregation prone and contains one of the minimal sequences needed for aggregation, S 71 82 , thought to be responsible for instigating aggregation of the full-length protein and therefore the focus of many early publications and attempts to inhibit S aggregation [52]

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10.1016/0006-2944(79)90046-2 Biochem