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Several alterations, potentially leading to epilepsy, have been reported in the hippocampal DG network of SynII KO, such as: (1) an increased excitation/inhibition (E/I) ratio in the MCs to the GCs microcircuit [12], (2) a decreased asynchronous GABA release [13] and subsequent reduction of GABAergic tonic inhibition [14], and (3) an alteration of adult hippocampal neurogenesis and BDNF levels [22, 23]

Biochem Biophys Res Commun 503:10421048

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The mammalian Nox family comprises seven members: Nox1, Nox2 (formerly gp91phox), Nox3, Nox4, Nox5, Duox1, and Duox2 [132]

10.1371/journal.pone.0146797 Summary Keywords autism, folinic Acid, glutathione, methylation, methylcobalamin, oxidative stress, tetrahydrobiopterin Citation Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ and Frye RE (2018) Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials