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Side effects may include local injection site reactions, gastrointestinal disturbances, hypersensitivity reactions, hemolytic anemia in G6PD-deficient patients, and kidney stone formation in susceptible individuals

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doi: 10.1016/j.cmet.2007.12.007

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Though this advantage is narrowing as oral GLP-1 formulations become available, including the GLP-1 six-in-one oral liquid and various tablet formulations like tirzepatide tablets , injection aversion remains a real barrier for many patients