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Some of the major benefits were, increased target drug concentrations, low individual variability, decreased gastrointestinal transit time variation, decreased after effects, low chances of dose dumping, various routes of administration (oral, parenteral and inhalation), suitable for hydrophilic and hydrophobic drug loading [316]

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2.5.2 Clinical studies Monogenic PD cases due to GBA1 loss of function and subsequent substrate accumulation have been investigated in cellular and animal models and in studies of human brains of patients with GBA1 -associated PD showing to particularly affect pars compacta of SN, putamen, cerebellum, and amygdala and frontal cortex (Gegg et al., 2012

Pflugers Arch , 459:793806

A , N39 Ileum organoids, stably expressing the live cell cycle progression-reporter FUCCI, were cultured on BME-coated transwell inserts

doi: 10.2741/A829 95