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doi: 10.1080/21678421.2023.2239292 50

During hypoxia, oxygen sensing and signal transduction are largely governed by prolyl hydroxylase domain proteins (PHD1/2/3), which hydroxylate target proteins in an oxygen-dependent manner 8,9

However, higher doses can reduce the effects caused by oxidative stress and inflammation in COPD, demonstrating a positive impact on the rate of exacerbation [117]

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